|
Ramakrishna Sompallae, Ph.D. Student (»Add to Infobox)
|
|
|
Virology, Host-pathogen intereactions:
Viral infections often drive host cells to stimulate apoptotic pathways in order to eliminate the infected cells. In response to this, viruses have developed ways to escape the host defense. These viral effects on cells can in some cases transform the host cell into a tumor cell. Since the ubiquitin proteasome system is involved in the host defense mechanisms and it contains so many proteins this provides opportunities for viral interference. Thus it is interesting and important to identify viral proteins that interfere cellular ubiquitination and deubiquitnation process. As there are limited tools available to identify this class of proteins we want to use bioinformatics methods in the prediction of novel deubiquitinating enzymes (DUBs). We have applied bioinformatics based approaches to identify DUBs in viruses. We made amino acid patterns and HMM profiles for the catalytic domains of DUBs. As an initial search model for viral genomes we took Epstein-Barr Virus (EBV) genome.
Bioinformatics
|
Identification and functional characterization of ubiquitin and ubiquitin-like conjugating and deconjugating enzymes in Epstein-Barr Virus
Maria Masucci, Professor (Department of Cell and Molecular Biology)
Members
|
|
|
|
Home
ki.se