Tracing the routes from mainland Africa to South-east Asia, Island Melanesia and Madagascar, we aim at a better understanding of how humans, parasites and mosquitoes have co-evolved over time and
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The overall goal of this project is to study the role of calcium (Ca2+) signaling for drug resistance in the human malaria parasite (Plasmodium falciparum). A major obstacle in today’s malaria control
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Malaria parasites evade human immune clearance by antigenic variation. We have recently identified a conserved molecule which is expressed on the infected erythrocyte surface. Functional analysis of
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A virulence factor of Plasmodium falciparum parasites expressed on the infected erythrocyte has been investigated in the vaccine development. A recombinant Mini-gene was cloned in the vaccine
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Dramatic differences in acute virulence between parasite strains exist in nature, yet little is known about the underlying biological or genetic factors that mediate these differences. Using
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In this project we study the presence of gene copy number polymorphisms (CNPs). Further analysis of the impact of discovered genetic differences and the underlying mechanisms is likely to generate a
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